Opportunity Information: Apply for PAR 24 134
The Small Business Transition Grant for New Entrepreneurs (R41/R42 Clinical Trial Required), listed as PAR-24-134, is an NIH funding opportunity designed to help early-stage, would-be entrepreneurs make a structured transition into small-business innovation while also moving a specific health-related technology forward through research and development. The core idea is to pair two things that do not always develop together on their own: (1) hands-on product-focused R and D that supports NIH's mission to improve health and save lives, and (2) intentional entrepreneurial training, mentoring, and career development for the person leading the project. In practice, NIH is using this program to strengthen the talent pipeline for biomedical and health innovation by helping researchers build the skills needed to operate successfully in a small business environment and to lead independent, product-driven research programs.
This opportunity uses the SBIR Phased Innovation structure, specifically the R41/R42 mechanism, and it is explicitly marked "Clinical Trial Required." That means projects proposed under this NOFO are expected to include a clinical trial component that is appropriate to the technology and stage of development, and applicants should be prepared to design, justify, and manage that clinical trial work as part of the funded activities. The award is intended to support small business concerns (SBCs) that hire and develop an investigator as the entrepreneurial Program Director/Principal Investigator (PD/PI). The PD/PI is not expected to arrive as a fully formed business leader; instead, NIH is targeting individuals who already have strong scientific, technology development, and/or healthcare delivery expertise but have limited experience with entrepreneurship and limited experience leading independent research projects in a small business context. The expectation is that the PD/PI will grow into that role during the award period through structured development activities while delivering concrete R and D progress toward a viable product.
A major emphasis of the program is the PD/PI's entrepreneurial development alongside the technical milestones. NIH is effectively signaling that the training plan and mentorship structure are not secondary add-ons, but a central part of what is being funded. The small business is expected to provide an environment where the PD/PI can build practical skills such as product development strategy, project leadership, team coordination, and the translation steps needed to move biomedical innovations toward real-world use. The funded work should be aligned with NIH's public health mission, meaning the technology or product under development should have a clear pathway to improving health outcomes, healthcare delivery, or biomedical understanding in a way that ultimately benefits patients and the public.
Eligibility is limited to small businesses as applicants. Foreign organizations (non-U.S. entities) are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible. However, NIH notes that "foreign components," as defined in the NIH Grants Policy Statement, may be allowed, which typically means that certain limited, well-justified project elements can occur outside the U.S. if they are essential and meet NIH policy requirements. The administering agency is the National Institutes of Health, and the opportunity is categorized as a discretionary grant within the broader areas of education and health-related support. Multiple CFDA listings are associated with the announcement (including 93.172, 93.173, 93.213, 93.233, 93.273, 93.279, 93.361, 93.837, 93.838, 93.839, 93.840, 93.865, 93.866, 93.867, 93.879), reflecting the fact that various NIH institutes and centers may participate depending on the topic area.
Key logistical details included in the source information are that the opportunity was created on April 25, 2024, and shows an original closing date of April 5, 2027. The listing does not specify an award ceiling or the expected number of awards in the provided fields, so applicants should rely on the full NOFO text and any institute-specific guidance for budget expectations, project period norms, and submission cycles. Overall, this program is best understood as a transition and capacity-building grant for new-to-entrepreneurship investigators, anchored in real SBIR-style development work, with NIH expecting both measurable technical progress toward a health-related product and meaningful growth of the PD/PI into an effective entrepreneurial leader within a small business.Apply for PAR 24 134
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Small Business Transition Grant for New Entrepreneurs (R41/R42 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172, 93.173, 93.213, 93.233, 93.273, 93.279, 93.361, 93.837, 93.838, 93.839, 93.840, 93.865, 93.866, 93.867, 93.879.
- This funding opportunity was created on 2024-04-25.
- Applicants must submit their applications by 2027-04-05.
- Eligible applicants include: Small businesses.
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| Funding Opportunity |
|---|
| Small Business Transition Grant for New Entrepreneurs (R43/R44 Clinical Trial Required) Apply for PAR 24 132 Funding Number: PAR 24 132 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Lasker Clinical Research Scholars Program (Si2/R00 Clinical Trial Optional) Apply for PAR 24 202 Funding Number: PAR 24 202 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required) Apply for PAR 24 214 Funding Number: PAR 24 214 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $375,000 |
| BRAIN Initiative: Brain-Behavior Quantification and Synchronization Transformative and Integrative Models of Behavior at the Organismal Level (U01 Clinical Trials Not Allowed) Apply for RFA DA 24 041 Funding Number: RFA DA 24 041 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Brain-Behavior Quantification and Synchronization Transformative and Integrative Models of Behavior at the Organismal Level (U01 Clinical Trial Optional) Apply for RFA DA 24 040 Funding Number: RFA DA 24 040 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Basic Experimental Studies with Humans (BESH) Required) Apply for PAR 24 218 Funding Number: PAR 24 218 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Clinical Trials Not Allowed) Apply for PAR 24 219 Funding Number: PAR 24 219 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Brain Behavior Quantification and Synchronization (R61/R33 Clinical Trial Optional) Apply for RFA MH 26 100 Funding Number: RFA MH 26 100 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Multidisciplinary Approaches for Developmental Research with Individuals with DSD (R21) Apply for RFA HD 16 023 Funding Number: RFA HD 16 023 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $200,000 |
| Multidisciplinary Approaches for Developmental Research with Individuals with DSD (R03) Apply for RFA HD 16 022 Funding Number: RFA HD 16 022 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $50,000 |
| Multidisciplinary Approaches for Developmental Research with Individuals with DSD (R01) Apply for RFA HD 16 021 Funding Number: RFA HD 16 021 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $499,999 |
| BRAIN Initiative: Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3) Apply for RFA NS 16 009 Funding Number: RFA NS 16 009 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $2,000,000 |
| BRAIN Initiative: Pre-Applications for Industry Partnerships to Provide Early Access to Devices for Stimulation and Recording in the Human Central Nervous System (X02) Apply for PAR 15 345 Funding Number: PAR 15 345 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Clinical Studies to Advance Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (UH3) Apply for RFA NS 16 010 Funding Number: RFA NS 16 010 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $2,000,000 |
| Adolescent Medicine Trials Network for HIV/AIDS Interventions(ATN) Coordinating Center (CC) (U24) Apply for RFA HD 16 040 Funding Number: RFA HD 16 040 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Foundations of Non-Invasive Functional Human Brain Imaging and Recording - Bridging Scales and Modalities (R01) Apply for RFA MH 16 750 Funding Number: RFA MH 16 750 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $700,000 |
| BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (U01) Apply for RFA NS 16 008 Funding Number: RFA NS 16 008 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Pediatric HIV/AIDS Cohort Study (PHACS) (U19 Clinical Trial Not Allowed) Apply for RFA HD 25 003 Funding Number: RFA HD 25 003 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $5,500,000 |
| U.S.-South Africa Program for Collaborative Biomedical Research Phase 3 (HIV/AIDS) (R01 Clinical Trial Optional) Apply for RFA AI 24 023 Funding Number: RFA AI 24 023 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $400,000 |
| BRAIN Initiative: New Technologies and Novel Approaches for Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed) Apply for RFA NS 25 018 Funding Number: RFA NS 25 018 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
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