Opportunity Information: Apply for RFA CA 23 024
The Limited Competition: Cooperative Human Tissue Network (CHTN; UM1 Clinical Trial Not Allowed) funding opportunity (RFA-CA-23-024) is a National Cancer Institute (NCI), National Institutes of Health (NIH) notice that supports the continued operation of the Cooperative Human Tissue Network through cooperative agreement awards (UM1 mechanism). It is a "limited competition" because it is specifically aimed at competing continuation applications from current NCI-supported CHTN awardees rather than opening the competition broadly to entirely new organizations. In practical terms, NCI is looking to renew and maintain the existing national infrastructure that makes the CHTN function as a coordinated, multi-division biospecimen resource.
The central purpose of the CHTN is to prospectively collect and distribute high-quality human tissue specimens that researchers request for basic and translational cancer research. What makes CHTN distinct is the emphasis on prospective, investigator-driven collection: tissues are obtained in response to specific scientific needs rather than being limited to what happens to be available in a bank. The specimens supported under this program include a wide range of tissue types relevant to cancer and related biology, including pre-cancerous lesions, malignant tumors, benign neoplastic tissues, tissues affected by non-neoplastic diseases, and normal tissues (including uninvolved or normal-adjacent tissue when available). These materials are intended to accelerate scientific discovery and enable development and validation of molecular diagnostic tests as well as prognostic and predictive assays.
The NOFO describes the CHTN as a national resource made up of multiple recipient sites referred to as CHTN Divisions, which collectively form the Network; at the time of the announcement, the network structure consists of six divisions. Since the CHTN was established by NCI in 1987, it has distributed more than 1,350,000 high-quality tissue specimens spanning many organ sites to over four thousand investigators, illustrating both the scale of operations and the breadth of research supported. The expectation embedded in the continuation competition is that awardees will keep delivering this kind of reliable, high-volume, high-quality biospecimen procurement and distribution service to the broader research community.
From an administrative standpoint, the award type is a cooperative agreement, meaning NCI anticipates substantial scientific or programmatic involvement in how the resource is run compared with a standard research project grant. The opportunity is explicitly marked "Clinical Trial Not Allowed," which signals that the award is intended to support the biospecimen resource and associated operations rather than clinical trial execution. The funding instrument is categorized as discretionary, and the activity area is listed under education and health. The CFDA (assistance listing) numbers associated with the opportunity are 93.393, 93.394, and 93.396. The posted award ceiling is $800,000, and the original application due date listed is 2023-07-07, with a creation date of 2023-05-31.
Eligibility in the source listing is broad across many U.S.-based organization types, including state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments and certain tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; and small businesses. The notice also highlights additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. At the same time, it clearly restricts foreign participation: non-U.S. entities (foreign organizations and foreign institutions) are not eligible to apply; non-domestic components of U.S. organizations are not eligible; and foreign components, as defined by NIH policy, are not allowed.
Overall, the opportunity is designed to preserve and strengthen a long-running NCI-supported national biospecimen pipeline by renewing existing CHTN divisions under a UM1 cooperative agreement framework, ensuring investigators can continue to obtain tailored, high-quality human tissue specimens for cancer-related discovery, translational studies, and assay development.Apply for RFA CA 23 024
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Limited Competition: Cooperative Human Tissue Network (CHTN; UM1 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.396.
- This funding opportunity was created on 2023-05-31.
- Applicants must submit their applications by 2023-07-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $800,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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