Opportunity Information: Apply for PAR 21 341
The NIH funding opportunity titled "Exploratory Grants in Cancer Control (R21 Clinical Trial Optional)" (PAR-21-341) supports early-stage, high-potential research ideas aimed at improving cancer control. It is designed for exploratory and developmental projects that are not yet ready for larger, more definitive funding mechanisms, but that could open up promising new directions in population-based cancer research. The focus is on work that could meaningfully influence how cancer risk is reduced, how early detection and screening are improved, and how underlying causes and contributing factors to cancer development are better understood, ultimately leading to stronger approaches for preventing and controlling cancer.
This FOA is centered on cancer control research that can span behavioral, biomedical, epidemiologic, health care delivery, and clinical domains. It specifically encourages projects that attempt to modify behavior related to cancer risk and outcomes, refine or expand screening strategies, and investigate etiologic factors that contribute to cancer. The program is intentionally broad in order to capture innovative concepts, especially those that could introduce or validate novel tools and approaches. Examples of the kinds of outputs NIH is looking to stimulate include new techniques, agents, methodologies, models, or practical applications that could have a major impact on a given cancer research area, even if the work is still at an early proof-of-concept stage.
As an R21 mechanism, the emphasis is on innovation, feasibility, and potential for impact rather than on having extensive preliminary data. The "clinical trial optional" designation means applicants may propose studies that include a clinical trial, but they are not required to do so. In practice, this gives investigators flexibility to pursue either non-trial exploratory work (such as formative studies, model development, measurement work, secondary analyses, or early translational concepts) or to propose an early-stage clinical trial when it is justified and fits the exploratory nature of the R21.
Eligibility is broad and includes many types of organizations that can contribute to cancer control science and community impact. Eligible applicants include state, county, city or township governments, special district governments, and independent school districts, as well as public and state-controlled institutions of higher education and private institutions of higher education. Tribal participation is supported through eligibility for federally recognized Native American tribal governments and Native American tribal organizations that are not federally recognized tribal governments. The FOA also welcomes public housing authorities and Indian housing authorities, nonprofits with or without 501(c)(3) status (other than institutions of higher education), and for-profit organizations other than small businesses, along with small businesses.
The opportunity also explicitly highlights additional eligible applicant categories that reflect a strong interest in reaching diverse institutions and community-connected organizations. These include Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; tribal governments that are not federally recognized; U.S. territories or possessions; and non-U.S. entities (foreign organizations). This wide eligibility scope signals that NIH is open to proposals from many settings, including those closely linked to underserved communities and populations that experience cancer disparities.
From the source information provided, the opportunity is a discretionary grant supported by the National Institutes of Health, tied to CFDA numbers 93.393 and 93.399. The original closing date listed is 2024-10-08, and the opportunity was created on 2021-10-12. While the award ceiling and expected number of awards are not specified in the provided data, the core takeaway is that this FOA is meant to seed innovative, early-stage cancer control research with the potential to grow into larger programs of study and ultimately improve cancer prevention, detection, and control at the population level.Apply for PAR 21 341
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Exploratory Grants in Cancer Control (R21 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.399.
- This funding opportunity was created on 2021-10-12.
- Applicants must submit their applications by 2024-10-08. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 21 341) also looked into and applied for these:
| Funding Opportunity |
|---|
| NIH Health Care Systems Research Collaboratory - Pragmatic and Implementation Trials of Embedded Interventions (UG3/UH3, Clinical Trials Optional) Apply for RFA AT 22 001 Funding Number: RFA AT 22 001 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Clinical Research Education and Career Development (CRECD) Program (R25-Independent Clinical Trial Not Allowed) Apply for PAR 21 347 Funding Number: PAR 21 347 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Integrating Biospecimen Science Approaches into Clinical Assay Development (U01 Clinical Trial Not Allowed) Apply for PAR 22 049 Funding Number: PAR 22 049 Agency: National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| A Multilevel Approach to Connecting Underrepresented Populations to Clinical Trials (CUSP2CT; U01 Clinical Trial Optional) Apply for RFA CA 21 063 Funding Number: RFA CA 21 063 Agency: National Institutes of Health Category: Education, Health Funding Amount: $450,000 |
| Clinical Sites for HIV/Cervical Cancer Prevention 'CASCADE' Clinical Trials Network (UG1 Clinical Trial Required) Apply for RFA CA 21 047 Funding Number: RFA CA 21 047 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Coordinating Center for HIV/Cervical Cancer Prevention 'CASCADE' Clinical Trials Network (U24 Clinical Trial Required) Apply for RFA CA 21 045 Funding Number: RFA CA 21 045 Agency: National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| Research Bases for HIV/Cervical Cancer Prevention 'CASCADE' Clinical Trials Network (UG1 Clinical Trial Required) Apply for RFA CA 21 046 Funding Number: RFA CA 21 046 Agency: National Institutes of Health Category: Education, Health Funding Amount: $400,000 |
| Limited Competition: NIH Health Care Systems Research Collaboratory - Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA AT 22 002 Funding Number: RFA AT 22 002 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| HEAL Initiative: Sickle Cell Disease Pain Management Trials Utilizing the Pain Management Effectiveness Research Network Cooperative Agreement (UG3/UH3, Clinical Trial Required) Apply for RFA AT 22 005 Funding Number: RFA AT 22 005 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| HEAL Initiative: Pragmatic and Implementation Studies for the Management of Sickle Cell Disease Pain (UG3/UH3, Clinical Trials Optional) Apply for RFA AT 22 004 Funding Number: RFA AT 22 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Modulating Human Microbiome Function to Enhance Immune Responses Against Cancer (R21 Clinical Trial Not Allowed) Apply for PAR 22 062 Funding Number: PAR 22 062 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Modulating Human Microbiome Function to Enhance Immune Responses Against Cancer (R01 Clinical Trial Not Allowed) Apply for PAR 22 061 Funding Number: PAR 22 061 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Innovative Biospecimen Science Technologies for Basic and Clinical Cancer Research (R61 Clinical Trial Not Allowed) Apply for RFA CA 22 003 Funding Number: RFA CA 22 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Advanced Development and Validation of Emerging Biospecimen Science Technologies for Basic and Clinical Cancer Research (R33 Clinical Trial Not Allowed) Apply for RFA CA 22 004 Funding Number: RFA CA 22 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| NCI Pathway to Independence Award for Outstanding Early Stage Postdoctoral Researchers (K99/R00 - Independent Basic Experimental Studies with Humans Required) Apply for RFA CA 21 062 Funding Number: RFA CA 21 062 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Pathway to Independence Award for Outstanding Early Stage Postdoctoral Researchers (K99/R00 - Independent Clinical Trial Required) Apply for RFA CA 21 061 Funding Number: RFA CA 21 061 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Pathway to Independence Award for Outstanding Early Stage Postdoctoral Researchers (K99/R00 - Independent Clinical Trial Not Allowed) Apply for RFA CA 21 060 Funding Number: RFA CA 21 060 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NIH HEAL Initiative: Preventing Opioid Misuse and Co-Occurring Conditions by Intervening on Social Determinants (R01 Clinical Trials Optional) Apply for RFA DA 22 036 Funding Number: RFA DA 22 036 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Drug Discovery For Nervous System Disorders (R21 Clinical Trials Not Allowed) Apply for PAR 22 032 Funding Number: PAR 22 032 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Toward Translation of Nanotechnology Cancer Interventions (TTNCI) (R01 Clinical Trial Not Allowed) Apply for PAR 22 071 Funding Number: PAR 22 071 Agency: National Institutes of Health Category: Education, Health Funding Amount: $475,000 |
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