Opportunity Information: Apply for W81XWH 20 NFRP CTA
The DoD Neurofibromatosis Research Program (NFRP) Clinical Trial Award is a Department of Defense funding opportunity intended to speed up the launch and execution of clinical trials that could materially improve how neurofibromatosis (NF) is treated or managed. The emphasis is on getting well-justified trials moving quickly, with a clear line of sight to real-world patient benefit. Rather than focusing on basic discovery work, this mechanism is oriented toward clinical evaluation, where the goal is to generate human-subject evidence that can change clinical practice, support later-phase development, or clarify whether a new approach is feasible and worth scaling.
Projects supported under this award can test a broad range of interventions and strategies. Trials may evaluate promising new products, including pharmacologic agents such as drugs or biologics, medical devices, clinical guidance (for example, structured care pathways or management strategies), and emerging approaches or technologies that may improve outcomes for people living with NF. The scope is intentionally wide to allow applicants to propose trials that address meaningful clinical needs, whether that is symptom control, disease progression, tumor management, functional outcomes, or quality-of-life improvements, as long as the trial has credible potential for significant impact.
The opportunity is structured to accommodate different stages of clinical testing. On the early end, it allows for small proof-of-concept studies, such as pilot trials, first-in-human work, or Phase 0 studies, where the main purpose is to demonstrate feasibility, gather preliminary safety or signal data, or generate information needed to design a stronger, more definitive trial. On the later end, it also supports larger-scale clinical trials intended to determine efficacy in relevant NF patient populations. In other words, applicants can propose anything from tightly focused feasibility studies through more robust trials designed to answer efficacy questions, provided the design matches the maturity of the intervention and the clinical question being asked.
Administratively, the opportunity is issued by the Department of Defense, Department of the Army, through the U.S. Army Medical Research Acquisition Activity (USAMRAA). It is listed as a discretionary program in the science and technology/research and development category (CFDA 12.420). The funding instruments available include grants and cooperative agreements, meaning awards may involve either a more traditional grant structure or a cooperative arrangement with substantial government involvement depending on the project and terms. Eligibility is listed as unrestricted, indicating that it is broadly open to a wide range of applicant organizations, subject to any additional eligibility clarifications that may be included in the full announcement.
The posting details included a creation date of March 30, 2020, with an original closing date of July 9, 2020. The expected number of awards is listed as one, suggesting a highly competitive selection and the likelihood that only a single proposal would be funded under that specific announcement cycle. The award ceiling is shown as 0 in the provided source data, which typically signals that the maximum funding amount was not captured in that field or was specified elsewhere in the full funding announcement rather than as a fixed cap in the summary record.Apply for W81XWH 20 NFRP CTA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Neurofibromatosis, Clinical Trial Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Mar 30, 2020.
- Applicants must submit their applications by Jul 09, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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