Opportunity Information: Apply for RFA HD 21 011
The Contraceptive Development Research Centers (CDRC) Program (P50 Clinical Trial Optional) is a National Institutes of Health (NIH) funding opportunity from the U.S. Department of Health and Human Services designed to accelerate the creation of new and improved contraceptive options for both women and men. The program is built around establishing a multidisciplinary Contraceptive Research Development Center, meaning applicants are expected to bring together teams that can move ideas from basic science through product-oriented development in a coordinated, center-based structure rather than as disconnected individual projects. A major emphasis is on contraceptive innovation and improvement, including approaches that could expand choice, address unmet needs, and overcome limitations of existing methods.
A key feature of the announcement is that it supports not only early-stage discovery and preclinical research, but also translational work aimed at bridging the gap between laboratory findings and human studies. In practical terms, the FOA explicitly welcomes research that helps move candidate products or technologies from preclinical proof-of-concept into clinical readiness, with the goal of improving the odds that methods entering clinical testing will succeed. The "clinical trial optional" designation signals that a center may include clinical trials if they are appropriate to the proposed research program, but clinical trials are not required for every application.
In addition to biomedical and product-development science, the FOA allows behavioral and social science projects focused on real-world contraceptive use, non-use, and user experience. This includes studying why people do or do not adopt marketed contraceptives, as well as investigating factors that may influence uptake and adherence for products still in clinical development. By including these components, the program recognizes that successful contraception is not just a technical problem; it also depends on acceptability, preferences, access, side effects, partner dynamics, and broader social and health system factors.
The center is also intended to function as a national resource for training and career development, particularly to help early stage investigators build careers in contraceptive research. In effect, awardees are expected to create an environment that supports mentoring, skill-building, and professional growth so that the field develops a stronger pipeline of researchers capable of sustaining innovation over the long term.
Administratively, this is a discretionary grant mechanism using the NIH P50 center model. The funding opportunity number is RFA HD 21 011, and the CFDA number listed is 93.865. The announcement lists an award ceiling of $1,300,000 and anticipates making 1 award, indicating a highly competitive process with substantial resources concentrated in a single center. The opportunity was created on February 24, 2020, with an original closing date of January 6, 2021.
Eligibility is broad and includes many types of organizations that can credibly run complex, multi-project research centers. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding higher education institutions in those nonprofit categories); for-profit organizations (other than small businesses); small businesses; and other entities as allowed in the FOA's additional eligibility text. Overall, the program is structured to support a coordinated, interdisciplinary center capable of developing contraceptive technologies, advancing translation toward the clinic, examining human factors that drive real-world use, and training the next generation of contraceptive researchers.Apply for RFA HD 21 011
- The Department of Health and Human Services, National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Contraceptive Development Research Centers (CDRC) Program (P50 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865.
- This funding opportunity was created on Feb 24, 2020.
- Applicants must submit their applications by Jan 06, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,300,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Frequently Asked Questions (FAQs)
What is the Contraceptive Development Research Centers (CDRC) Program?
The Contraceptive Development Research Centers (CDRC) Program (P50 Clinical Trial Optional) is an NIH funding opportunity from the U.S. Department of Health and Human Services designed to accelerate the creation of new and improved contraceptive options for both women and men. It supports the establishment of a multidisciplinary, center-based program (a Contraceptive Research Development Center) rather than disconnected individual projects.
What is the main goal of this funding opportunity?
The main goal is contraceptive innovation and improvement, including approaches that expand choice, address unmet needs, and overcome limitations of existing methods. The FOA emphasizes moving ideas from basic science through product-oriented development in a coordinated center structure.
What kind of structure is expected from applicants?
Applicants are expected to propose a multidisciplinary research center using the NIH P50 center model. The center should coordinate multiple components and teams to move concepts from discovery through development, rather than operating as isolated or unrelated projects.
What does "P50" mean in this context?
P50 refers to the NIH center grant mechanism used for this opportunity. The announcement describes it as a discretionary grant mechanism using the NIH P50 center model, intended to support a coordinated, multi-project research center.
What does "Clinical Trial Optional" mean?
"Clinical trial optional" means a proposed center may include clinical trials if they are appropriate to the research program, but clinical trials are not required for every application. The FOA supports work ranging from preclinical research through activities that move products toward clinical readiness.
Does this program support only early-stage research?
No. The FOA supports early-stage discovery and preclinical research as well as translational work intended to bridge the gap between laboratory findings and human studies. It explicitly welcomes research that helps move candidate products or technologies from preclinical proof-of-concept into clinical readiness.
What is meant by "translational work" in this announcement?
Translational work here refers to research aimed at improving the likelihood that methods entering clinical testing will succeed by advancing candidates from preclinical proof-of-concept toward clinical readiness, helping bridge the laboratory-to-human studies gap.
Is behavioral and social science research allowed under this FOA?
Yes. In addition to biomedical and product-development science, the FOA allows behavioral and social science projects focused on real-world contraceptive use, non-use, and user experience. This includes studying why people adopt or do not adopt marketed contraceptives and factors influencing uptake and adherence for products still in clinical development.
What kinds of real-world factors can be studied under the behavioral/social science allowance?
The FOA recognizes that contraceptive success depends on more than technology. It notes factors such as acceptability, preferences, access, side effects, partner dynamics, and broader social and health system factors as relevant to understanding use and non-use.
Does the program focus on contraception for women only?
No. The FOA is designed to accelerate new and improved contraceptive options for both women and men.
Is the center expected to provide training and career development?
Yes. The center is intended to function as a national resource for training and career development, particularly to help early stage investigators build careers in contraceptive research. Awardees are expected to create an environment that supports mentoring, skill-building, and professional growth.
Who is the sponsoring agency for this opportunity?
The opportunity is a National Institutes of Health (NIH) funding opportunity from the U.S. Department of Health and Human Services.
What is the funding opportunity number (FOA number)?
The funding opportunity number listed is RFA HD 21 011.
What is the CFDA number for this opportunity?
The CFDA number listed is 93.865.
How much funding is available (award ceiling)?
The announcement lists an award ceiling of $1,300,000.
How many awards does NIH anticipate making?
The announcement anticipates making 1 award, indicating the funding will be concentrated in a single center and the competition is likely to be highly competitive.
When was this opportunity created?
The opportunity was created on February 24, 2020.
What was the original closing date?
The announcement lists an original closing date of January 6, 2021.
What types of organizations are eligible to apply?
Eligibility is broad and includes: state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding higher education institutions in those nonprofit categories); for-profit organizations (other than small businesses); small businesses; and other entities as allowed in the FOA's additional eligibility text.
Are for-profit entities eligible to apply?
Yes. The eligibility list includes for-profit organizations (other than small businesses) and also separately includes small businesses.
Are nonprofit organizations eligible to apply?
Yes. The eligibility list includes nonprofits with and without 501(c)(3) status, with a note excluding higher education institutions in those nonprofit categories.
Are universities and colleges eligible to apply?
Yes. Both public and state-controlled institutions of higher education and private institutions of higher education are included as eligible applicants.
Are tribal governments and tribal organizations eligible to apply?
Yes. Federally recognized Native American tribal governments and other tribal organizations are listed as eligible applicants.
Are government entities eligible to apply?
Yes. The eligibility list includes state, county, and local governments as well as special district governments and independent school districts.
What is the program trying to improve about contraceptive development?
The FOA emphasizes improving the odds that methods entering clinical testing will succeed by supporting research that advances candidates from preclinical proof-of-concept into clinical readiness, alongside innovation to expand choice and address unmet needs.
Does the center need to be interdisciplinary?
Yes. A core expectation is a multidisciplinary team approach capable of moving ideas from basic science through product-oriented development in a coordinated, center-based structure.
What overall capabilities should the proposed center demonstrate?
Based on the FOA description, the center should be capable of coordinated contraceptive technology development, translational work toward the clinic, inclusion of research on human factors affecting real-world use (where relevant), and training/career development activities to build the field.
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